全场光学相干层析三维成像技术研究

牟宁; 高万荣; 魏喆强

doi:10.11959/j.issn.1000-436x.2017293

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全场光学相干层析三维成像技术研究

学术论文 | 更新时间：2024-06-05

- 全场光学相干层析三维成像技术研究
- Research on full-field optical coherence tomography
- 通信学报 2017年38卷第12期页码：121-127
- 作者机构：
  
  1. 南京理工大学电子工程与光电技术学院，江苏南京 210094
  2. 无锡市第三人民医院病理科，江苏无锡 214041
- 作者简介：
  
  [ "牟宁（1981-），女，江苏南京人，南京理工大学博士生，主要研究方向为全场相干光学层析、医学成像系统、生物医学图像处理等。" ]
  [ "高万荣（1961-），男，陕西铜川人，博士，南京理工大学教授、博士生导师，主要研究方向为生物医学和生物光学。" ]
  [ "魏喆强（1973-），男，江苏无锡人，无锡市第三人民医院主任医师，主要研究方向为临床病理诊断。" ]
- 基金信息：
  
  国家自然科学基金资助项目(61275198);国家自然科学基金资助项目(60978069)
- DOI：10.11959/j.issn.1000-436x.2017293
  中图分类号： TN247
- 网络出版日期：2017-12，
  
  纸质出版日期：2017-12-25
- 稿件说明：
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牟宁, 高万荣, 魏喆强. 全场光学相干层析三维成像技术研究[J]. 通信学报, 2017,38(12):121-127.

Ning MU, Wan-rong GAO, Zhe-qiang WEI. Research on full-field optical coherence tomography[J]. Journal on communications, 2017, 38(12): 121-127.
牟宁, 高万荣, 魏喆强. 全场光学相干层析三维成像技术研究[J]. 通信学报, 2017,38(12):121-127. DOI： 10.11959/j.issn.1000-436x.2017293.

Ning MU, Wan-rong GAO, Zhe-qiang WEI. Research on full-field optical coherence tomography[J]. Journal on communications, 2017, 38(12): 121-127. DOI： 10.11959/j.issn.1000-436x.2017293.

摘要

首先在对全场光学相干层析（FFOCT）系统的数学建模和理论分析基础上，给出FFOCT系统的轴向和平面分辨率；然后采用全场光学相干层析三维成像技术对人体食管、子宫等器官的正常和癌变样本进行内部三维成像提取，获取了微米级高分辨率的层析图像，可以清晰显示组织的细胞间质和肌纤维结构；研究实验中把FFOCT成像的结果与传统病理切片显微图像进行了比较，FFOCT系统不仅能观察到传统病理切片可以看到的细胞块形态，而且不需要切割、染色等烦琐耗时的处理，就能观察到传统方法难以获取的深度结构。该技术可以应用于癌症的早期诊断和手术中的快速诊断。

Abstract

Full-field optical coherence tomography(FFOCT)was used for imaging the interior part of an object.Firstly，the mathematical modeling and performance analysis of the FFOCT system mounted was provided.Secondly，images of several different human tissues were obtained by FFOCT system，including esophagus，uterus，etc.The images of different depths of the same tissue were shown and compared.It was the first time in China that FFOCT was used for generating depth images on human esophagus and uterus;high-resolution images had been obtained for different depths without cutting the tissue sample，in which intercellular substance and myofibril structure could be clearly identified.As the in-depth structure could be imaged without the process needed for frozen and paraffin sectioning methods，the technology could been highly valuable for early cancer diagnosis and pathological analysis in tumor research.

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references

杨珊珊 , 米磊 , 朱锐 , 等 . 光学相干断层成像技术在定窑瓷器检测中的应用 [J ] . 中国激光 , 2016 ,( 02 ): 195 - 201 .

YANG S S , MI L , ZHU R , et al . Non-invasive investigation of microstructure of ding kiln porcelain with optical coherence tomography [J ] . Chinese Journal of Lasers , 2016 ,( 02 ): 195 - 201 .

张海波 , 耿国华 , 赵映程 , 等 . 基于非凸L 1-2 正则子的锥束X射线发光断层成像 [J ] . 光学学报 , 2017 ,( 06 ): 1 - 17 .

ZHANG H B , GENG G H , ZHAO Y C , et al . Nonconvex L 1-2 regularization for fast cone-beam X-ray luminescence computed tomography imaging [J ] . Acta Optica Sinica , 2017 ,( 06 ): 1 - 17 .

贺小伟 , 金晨 , 易黄建 , 等 . 基于分割增广拉格朗日收缩的X射线发光断层成像 [J ] . 光学学报 , 2016 ,( 03 ): 155 - 163 .

HE X W , JIN C , YI H J , et al . X-ray luminescence computed tomography based on split augmented lagrangian shrinkage algorithm [J ] . Acta Optica Sinica , 2016 ,( 03 ): 155 - 163 .

TAXY J B . Frozen section and the surgical pathologist:a point of view [J ] . Arch Pathol Lab Med , 2009 , 133 ( 7 ): 1135 - 1138 .

MCLAUGHLIN S A , OCHOA‑FRONGIA L M , PATIL S M , et al . Influence of frozen‑section analysis of sentinel lymph node and lumpectomy margin status on reoperation rates in patients undergoing breast‑conservation therapy [J ] . J Am Coll Surg , 2008 , 206 ( 1 ): 251 .

BEAUREPAIRE E , BOCCARA A C , LEBEC M , et al . Full-field optical coherence microscopy [J ] . Optics Letters , 1998 , 23 ( 4 ): 244 - 246 .

DUBOIS A , VABRE L , BOCCARA A C , et al . High-resolution full-field optical coherence tomography with a Linnik microscope [J ] . Applied Optics , 2002 , 41 ( 4 ): 805 - 812 .

CHEN L , ZEITLER J A , YUE D , et al . Non-destructive evaluation of polymer coating structures on pharmaceutical pellets using full-field optical coherence tomography [J ] . Journal of Pharmaceutical Sciences , 2014 , 103 ( 1 ): 161 - 166

MORIN A . Tomographie par coherence optique spectroscopique en plein champ:application a l'analyse des pigments des couches picturales [D ] . Universite Pierre et Marie Curie-Paris VI , 2012 .

BINDING J , AROUS J B , LEGER J F , et al . Brain refractive index measured in vivo with high-NA defocus-corrected full-field OCT and consequences for two-photon microscopy [J ] . Opt Expr , 2011 , 19 ( 6 ): 4833 - 4847 .

JAIN M , SHUKLA N , MANZOOR M , et al . Modified full-field optical coherence tomography:a novel tool for rapid histology of tissues [J ] . J Pathol Inform , 2011 , 2 ( 2 ): 28 .

JAIN M , NARULA N , SALAMOON B , et al . Full-field optical coherence tomography for the analysis of fresh unstained human lobectomy specimens [J ] . J Pathol Inform , 2013 , 4 ( 4 ): 26 .

朱越 , 高万荣 , 郭英呈 . 提高全场光学相干层析系统成像质量的方法 [J ] . 光子学报 , 2015 , 35 ( 5 ):0517001.

ZHU Y , GAO W R , GUO Y C . A method of improving imaging quality of full-field optical coherence tomography [J ] . Acta Optica Sinica , 2015 , 35 ( 5 ):0517001.

ZHU Y , GAO W , ZHOU Y , et al . Rapid and high-resolution imaging of human liver specimens by full-field optical coherence tomography [J ] . ournal of Biomedical Optics , 2015 , 20 ( 11 ):116010-1-8.

MOREAU J , LORIETTE V , BOCCARA A C . Full-field birefringence imaging by thermal-light polarization-sensitive optical coherence tomography II.Instrument and results [J ] . Applied Optics , 2003 , 42 ( 19 ): 3811 - 3818 .

DUBOIS A , GRIEVE K , MONERON G , et al . Ultrahigh-resolution full-field optical coherence tomography [J ] . Applied Optics , 2004 , 43 ( 14 ): 2874 - 2883 .

DUBOIS A , VABRE L , BOCCARA A C , et al . High-resolution full-field optical coherence tomography with a Linnik microscope [J ] . Appl Opt , 2002 , 41 ( 4 ): 805 - 812 .

VABRE L , DUBOIS A , BOCCARA A C . Thermal-light full field optical coherence tomography [J ] . Opt.Lett. , 2002 , 27 ( 7 ): 530 - 533 .

GAO W . Image contrast reduction mechanism in full-field optical coherence tomography [J ] . Journal of Microscopy , 2016 , 261 ( 3 ): 199 - 216 .

LABIAU S , DAVID G , GIGAN S , et al . Defocus test and defocus correction in full-field optical coherence tomography [J ] . Opt Lett , 2009 , 34 ( 10 ): 1576 - 1578 .

GAO W . Effects of temporal and spatial coherence on resolution in full-field optical coherence tomography [J ] . Journal of Modern Optics , 2015 , 62 ( 21 ): 1764 - 1774 .

DE G P , DE L C . Signal modeling for low-coherence height-scanning interference microscopy [J ] . Appl Opt , 2004 , 43 ( 25 ): 4821 - 4830 .

DUBOIS A , BOCCARA A C . Full-field optical coherence tomography,optical coherence tomography:technology and applications [M ] . Springer , 2008 .

高万荣 , 陈一丹 , 刘畅 , 等 . 基于FPGA的快速全场光学相干层析系统的设计与实现 [J ] . 光子学报 , 2016 , 45 ( 6 ): 87 - 92 .

GAO W R , CHEN Y D , LIU C , et al . Design and implementation of FPGA-based rapid full field optical coherence tomography [J ] . Acta Photonica Sinica , 2016 , 45 ( 6 ): 87 - 92 .

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